DMT is a psychedelic compound found in plants and, researchers argue, in trace amounts in the human body, and this film follows the scientists and subjects who study what it does to consciousness. Dr. Rick Strassman anchors the story: in the early 1990s he ran the first government-sanctioned human study of a psychedelic drug in the United States, injecting volunteers at the University of New Mexico with DMT and recording their accounts afterward. Those accounts recur throughout, describing encounters with entities, dissolving boundaries, and experiences that feel more real than ordinary waking life. The film sets Strassman's clinical data alongside separate threads, near-death experiences, shamanic ayahuasca ceremonies, and the compound's ubiquity in nature, and lets researchers, participants, and commentators argue over what the parallels mean. Directed by Mitch Schultz, it treats DMT as both a chemistry question and a religious one, following the argument to its edge without settling whether the visions are neurology or something more.