Neuroscientist Colin Blakemore sets out to test a claim: that science has been the biggest challenge Christianity has ever faced. He traces the relationship from the centuries when the Bible stood as the primary source of knowledge through the Scientific Revolution and into the Enlightenment, when a new generation of scientists pushed church authority into retreat. In Rome, Blakemore visits the Museum of Criminology to examine 16th-century torture devices and a volume titled 'The Inquisition Handbook of Torture,' evidence of how heresy accusations once ended scholarly careers. He interviews Vatican astronomer Brother Guy Consolmagno inside the Vatican's own observatory and meteorite lab, where Consolmagno argues the Bible is 'a human interpretation of divine inspiration' rather than a science text. A stop at Kentucky's Creation Museum, with its exhibits of humans and dinosaurs coexisting, shows the argument is far from settled, and Blakemore's visible unease there plays as the film's sharpest moment. The film closes at CERN's Large Hadron Collider in Geneva, weighing whether faith and scientific inquiry can ever really coexist.