Ayahuasca is a hallucinogenic brew that shamans across the Amazon basin have used for generations in healing and spiritual ceremonies, combining a vine and a leaf into a drink that produces hours of vivid visions and, often, vomiting and purging that practitioners treat as part of the cure. This film follows those ceremonies and the shamans who lead them, showing the rituals, chants, and plant preparation that surround each session, and gathers accounts from participants describing what the drug does to their thinking and sense of self. It tracks how a substance once confined to indigenous communities has drawn Westerners willing to travel to the Amazon or to retreats elsewhere seeking the same experience, and it sits with the resulting friction: legal status that varies by country, debate over whether outsiders can use the plant safely without a trained guide, and a growing body of clinical research testing ayahuasca's effects on depression and trauma. The film treats the tradition and the science as two lenses on the same plant rather than picking a side.