Ayahuasca, the psychoactive brew indigenous Amazonian peoples call the "spirits of the woody vine," is drawing growing numbers of foreigners and Brazilians into the state of Acre, where the Huni Kuin people gather once a month by the river to drink it from small glasses in ceremonies that last for hours. Tribal elder Ibã Huni Kuin describes it as a healing journey of self-discovery, and the film follows him as he also turns the ceremonies into income through art sales, money that goes toward protecting the rainforest. The camera then moves to Rio de Janeiro, near Sugarloaf Mountain, where a decades-old ayahuasca church blends Catholic hymns and nature worship into its own long ceremonies of dancing and chanting. Researchers interviewed in the film weigh the drug's potential as a treatment for depression and addiction against the risks of an unregulated boom in ayahuasca tourism. The film moves between rainforest village and city congregation to ask what happens when a sacred, legal ritual becomes a commercial and medical product.