Can’t Stop Eating

In the poignant documentary “Can’t Stop Eating,” viewers are immersed in the lives of a small group of British individuals grappling with the challenges of an incurable genetic disorder known as Prader-Willi syndrome. This rare condition, first described in 1956, arises from the deletion or lack of expression of specific genes on chromosome 15, with a unique twist—parental origin imprinting. The paternal chromosome is crucial, as it determines which copy of the affected genes is expressed and which remains silent. With an incidence ranging from 1 in 25,000 to 1 in 10,000 live births, Prader-Willi syndrome presents a complex genetic landscape that shapes the lives of those living with it.

The documentary unfolds as a sensitive exploration of the intricacies surrounding Prader-Willi syndrome, shedding light on the genetic intricacies that underlie this condition. The film dives into the historical roots of the syndrome, acknowledging the Swiss researchers who first documented it. The paternal origin of the affected genetic material is pivotal, leading to the selective expression of maternal genes and the silencing of paternal copies. For those with Prader-Willi syndrome, this means lacking a functional copy of these genes, setting them apart from the genetic makeup of the majority.

One of the documentary’s strengths lies in its human-centric narrative, focusing on the lives of individuals grappling with Prader-Willi syndrome. By intimately showcasing the daily challenges, triumphs, and nuances of those affected, the film creates a bridge of understanding between the audience and the complexities of this rare genetic disorder. Moreover, it touches upon the unique relationship Prader-Willi syndrome shares with Angelman syndrome, offering a broader perspective on the genetic intricacies of these sister syndromes.