Craig Venter tells David Frost how he raced a publicly funded international consortium to sequence the human genome, founding Celera Genomics in 1998 and using a shotgun-sequencing method that finished the job years ahead of schedule. Frost presses him on the ethics of racing science for profit and on the 2000 White House ceremony where Venter and Francis Collins jointly announced a draft genome to defuse the rivalry. The conversation moves from that history into Venter's next project: building a synthetic cell from scratch, assembling a bacterium's genome chemically and inserting it into a host cell to create what he calls artificial life. Venter talks through what that milestone means for medicine, biofuels, and the definition of a living organism, and Frost keeps returning to whether one scientist should hold this much power over the basic code of life. It is a studio interview, one man's account of two of the biggest claims in modern biology, delivered directly to camera.