Joe Cross weighs 310 pounds, depends on steroids to manage an autoimmune disease, and decides the fix is sixty days of nothing but fruit and vegetable juice. He drives across the United States with a juicer in the back of his car, filming himself as the weight comes off and his medication needs change, while stopping to talk with ordinary Americans about what they eat and why. The turning point comes on the road in Arizona, where Cross meets Phil Staples, a truck driver over 400 pounds struggling with the same disease, and the film's second half follows Phil's attempt to do what Cross did. Doctors and nutrition experts appear throughout to explain what juicing does and does not accomplish, keeping the personal transformation story tied to actual physiology rather than just before-and-after shots. The film is plain in its methods, mostly handheld camera, direct-to-camera confession, and roadside interviews, and its case rests on the two men's measurable results rather than argument.