Efavirenz is an antiretroviral drug approved in 1998 to treat HIV, effective enough to become a mainstay of AIDS treatment across Africa, but patients on it soon reported vivid dreams, hallucinations, and a persistent sense of unreality. In South Africa those side effects turned the medication into a street commodity: users crush efavirenz tablets into a mixture called nyaope, often cut with marijuana, heroin, and whatever else is on hand, and smoke it for the high. Hamilton Morris travels to South African townships to interview nyaope users and dealers about how a life-saving medicine ended up in a drug cocktail, and talks to scientists trying to work out the pharmacology behind efavirenz's hallucinogenic effects. Tabloid reports linking the drug to rapes and robberies pushed researchers to take the phenomenon seriously, and the film traces that shift from anecdote to lab study. It stays close to the people using the drug on the street rather than treating them as a case study, and lets the gap between the pill's intended purpose and its second life speak for itself.