HIV/AIDS orthodoxy comes under direct challenge in this film, which interviews virtually every major figure in the debate on camera, from mainstream virologists to the scientists who reject the HIV-causes-AIDS model entirely. Robert Gallo, Luc Montagnier, and Kary Mullis appear alongside dissenting researcher Peter Duesberg and journalists Celia Farber and Neville Hodgkinson, each stating their position in their own words rather than through narration summarizing it for them. The film questions how HIV-infection statistics get compiled and reported, argues that poverty and malnutrition may account for AIDS deaths attributed to the virus, and raises concerns about the toxicity of antiretroviral drugs like AZT. Street interviews from England and Australia are cut against the expert testimony, checking what ordinary people think they know against what the scientists on both sides actually claim. No side is given the last word; the film's structure is the argument itself, competing experts stating incompatible positions on camera and daring the viewer to sort them out.