Laboratory mice living up to 50 percent longer than normal have researchers asking whether the same tricks could work on humans. This film follows scientists studying people who have passed a hundred years old, looking for what protects some lifelong smokers and sedentary subjects from the diseases that kill everyone else, and hunting for shared variants in their DNA. Host Anja Taylor puts one theory to the test on herself, undergoing a five-day fasting regimen of soups, teas, and small portions modeled on lab experiments that extended mouse lifespans by 11 percent while cutting disease and inflammation. Cameras track the physical effects as they happen: shifts in insulin and glucose levels, weight loss, and changes in white blood cell counts, alongside interviews with the researchers running the animal studies in parallel. The film treats aging as a biological process with levers that might be pulled rather than a fixed sentence, and it stays with the open questions, particularly why genetics alone doesn't explain who reaches extreme old age.