The University of Pennsylvania hosts an unusual gathering over four days in September 2012: the first academic conference funded by an American university built entirely around the risks and benefits of psychedelic experience. This film records that event, cutting between conference-hall presentations and interviews with the scientists, artists, journalists, historians, and philosophers who traveled from more than ten countries to attend. The talks range from neuroscience labs studying psilocybin's effects on the brain to shamanic healing traditions, with researchers, graduate students, and interested laypeople sitting in the same rooms debating what psychedelics do to knowledge production, mental health, and creativity. Psychiatrist Roland Griffiths appears among the speakers discussing clinical research into these compounds. Visionary art from contributors like Alex Grey and Android Jones punctuates the footage, tying the science sessions to the culture that grew up around the drugs long before universities would touch the subject. The film treats the conference itself as the story: a controversial topic getting a formal, interdisciplinary hearing on an Ivy League campus for the first time.