Antibiotics stopped a lot of dying in the twentieth century, and this film asks what happens as bacteria evolve past them. It lays out how overuse in hospitals and livestock farming has bred strains resistant to nearly everything in the medicine cabinet, tracing the biology of resistance from a single mutated cell to hospital wards where infections that used to be routine become untreatable. Researchers and physicians explain the mechanics of how bacteria trade resistance genes and why the pipeline of new antibiotics has slowed to a trickle, leaving doctors reusing older, more toxic drugs as a last resort. Case footage from clinical settings shows the human cost directly: patients whose infections no longer respond to standard treatment. The film treats this as a slow-moving crisis rather than a hypothetical one, connecting agricultural antibiotic use, weak incentives for drug development, and global travel into a single picture of how a resistant strain in one hospital can become a resistant strain everywhere.