Cholesterol has been cast as one of the great villains of modern medicine, and statins as the drugs that hold it in check, with an estimated 40 million people worldwide taking them. Filmmaker Justin Smith questions that consensus, interviewing cardiologists, researchers, and nutrition scientists who argue the link between cholesterol and heart disease has been overstated, and in some cases misrepresented, by decades of pharmaceutical-funded research. Doctors including Malcolm Kendrick and Uffe Ravnskov walk through the studies behind the cholesterol hypothesis and point to what they say are gaps between the data and the public message. The film traces how dietary guidelines shifted to demonize saturated fat, and asks why heart disease rates kept climbing anyway. Side effects of statin use, from muscle pain to memory problems, get their own attention through patient accounts. The film does not pretend the matter is settled among scientists, but it makes a sustained case that the standard advice deserves more scrutiny than it usually gets.