Horizon's guide to science and religion opens with American creationists who reject evolution outright, then travels to CERN, where physicists working on the Large Hadron Collider search for the fundamental particles and forces that built the universe. The film sets these two positions against each other as endpoints on a spectrum, tracing how three centuries of scientific discovery, from Newton's mechanics through Darwin's evolution to modern particle physics, have repeatedly narrowed the space left for divine explanation. Scientists and believers appear side by side, some insisting the two are irreconcilable, others describing how they hold both a faith and a career in physics or biology without contradiction. The question driving the film is blunt: does the expanding reach of scientific knowledge leave any room for God in the modern world, or has it quietly closed the case? Rather than settling the argument, the film uses the Large Hadron Collider as its clearest example of how far scientific explanation has already reached into territory once reserved for theology.