Four American families tell the story of the opioid epidemic through the people they lost or nearly lost. Produced by HBO Documentary Films and directed by Perri Peltz, the film leans on home video shot by the families themselves, birthday parties and school plays that later become the only record of someone who died of an overdose. Parents describe how a legitimate prescription for pain, after a sports injury or routine surgery, turned into dependence on pills and then heroin. One mother sits with the belongings of a son who overdosed alone in his bedroom; another family recounts an intervention that came too late. Doctors and addiction specialists appear briefly to explain how prescription opioids rewire the brain's response to pain and reward, but the film keeps its attention on the households living with the consequences rather than the policy fight. It is blunt about where addiction actually starts in most of these cases: a doctor's office, not a street corner.