Antibiotic-resistant bacteria are spreading faster than researchers can develop new drugs to fight them, and FRONTLINE traces the human cost through hospital wards and public health labs. A young girl in Arizona ends up on life support after a routine infection turns untreatable, and an outbreak tears through one of the country's most prestigious hospitals despite isolation protocols and aggressive treatment. Doctors, epidemiologists, and public health officials explain how decades of antibiotic overuse in medicine and agriculture bred bacteria that no longer respond to the drugs meant to kill them, and how the pipeline of new antibiotics has slowed to a trickle because they are not profitable to develop. The film moves between patient rooms, hospital labs, and policy hearings, laying out a system that keeps prescribing the same drugs even as they stop working. It is a plain, reported account of a problem with no easy fix: bacteria evolve resistance faster than companies build replacements, and the gap between the two is where patients like the Arizona girl end up.